This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction.

[8] Aurora C localizes to the centrosome and then to the midzone of mitotic cells from anaphase to cytokinesis.

It is expressed about an order of magnitude less than Aurora B in diploid human fibroblasts, with mRNA and protein concentrations peaking during the G2/M phase.

[16] Inactivating mutations of Aurora C have been shown to cause infertility in men characterized by macrocephalic and multiflagellular spermatozoa.

Homozygous and heterozygous c.144delC mutation in the AURKC gene was found with an allelic frequency of 2.14% in Moroccan men with unexplained spermatogenic failure.