[5][6][7] It is a regulatory protein in the chromosome passenger complex (CPC).

[13] These include CENPE; MCAK; KID; cytoplasmic dynein (e.g., DYNC1H1); CliPs (e.g. CLIP1); and CENPF/mitosin (CENPF).

The inner centromere proteins (INCENPs),[5] the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase.

During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis.

This interaction has been implicated in the coordination of chromosome segregation with cell division in yeast.