Aurora inhibitor

Aurora kinase inhibitors are a putative drug class for treating cancer.

Aurora kinases regulate cell cycle transit from G2 through cytokinesis, and thus are targets in cancer therapy.

[3] A new approach to inhibiting cancer growth that shows great promise for structure-based drug development is targeting enzymes central to cellular mitosis.

[4] Aurora kinases, so named because the scattered mitotic spindles generated by mutant forms resemble the Aurora Borealis, have gained a great deal of attention as possible anticancer drug targets.

[5][6] The Aurora enzymes are particularly significant because they are involved in a direct path to the nucleosome by phosphorylating histone H3.