R. Gordon Wasson, Richard Evans Schultes, and Albert Hofmann have suggested that the statue of Xochipilli, the Aztec 'Prince of Flowers,' contains effigies of a number of plant based entheogens.
It was also used as an anesthetic to ease pain by creating a paste from the seeds and tobacco leaf, then rubbing it on the affected body part.
Allegedly, during the emperor's coronation ceremony, many prisoners were sacrificed, had their flesh eaten, and their hearts removed.
After the defeat of the Aztecs, the Spanish forbade traditional religious practices and rituals that they considered "pagan idolatry", including ceremonial mushroom use.
R. Gordon Wasson identified the flower on the statue of Xochipilli and suggested from its placement with other entheogens that it was probably used in a ritualistic context.
This is interesting because today in Central and South America, sinicuichi is often called abre-o-sol, or the "sun opener."
It reads: Let one who is fear-burdened take as a drink a potion made of the herb tonatiuh yxiuh which throws out the brightness of gold.
The plants typically have large, white or purplish, trumpet-shaped flowers and spiny seed capsules, that of D. stramonium being held erect and dehisceing by four valves and that of D. innoxia nodding downward and breaking up irregularly.
Called toloache today in Mexico, datura species were used among the Aztec for medicine, divination, and malevolent purposes.
For healing, tlapatl was made into an ointment which was spread over infected areas to cure gout, as well as applied as a local anesthetic.
It is thought that since peyote only grows in certain regions of Mexico, the Aztecs would receive dried buttons through long-distance trade.
It is not entirely known whether or not this plant was used by the Aztecs as a psychotropic, but Jonathan Ott (1996) argues that although there are competing species for the identification of pipiltzintzintli, Salvia divinorum is probably the "best bet."
Contemporaneously, the Mazatec, meaning "people of the deer" in Nahuatl, from the Oaxaca region of Mexico utilize Salvia divinorum when Psilocybe spp.
Modern users of Salvia have adapted the traditional method, forgoing the swallowing of juices due to Salvinorin A being readily absorbed by the mucous membranes of the mouth.