It binds bone morphogenetic proteins, members of the TGF beta superfamily of ligands, which are involved in paracrine signaling.

[6] BMPR2 is expressed on both human and animal granulosa cells, and is a crucial receptor for bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9).

These two protein signaling molecules and their BMPR2-mediated effects play an important role in follicle development in preparation for ovulation.

There is evidence that the BMPR2 signaling pathway is disrupted in the case of polycystic ovary syndrome, possibly by hyperandrogenism.

[12] When this gene is inhibited, vascular smooth muscle proliferates and can cause pulmonary hypertension, which, among other things, can lead to cor pulmonale, a condition that causes the right side of the heart to fail.

[12] There have been studies which has correlated BMPR2 with exercise induced elevation of PA pressure by measuring tricuspid regurgitation velocity by echocardiography.