[2] The New York Yankees selected Gamel in the 10th round of the 2010 Major League Baseball draft.

[8] He spent the majority of the 2016 season with Scranton/Wilkes-Barre, and won the International League Most Valuable Player Award.

[9] On August 31, 2016, the Seattle Mariners acquired Gamel from the Yankees for minor league pitchers Jio Orozco and Juan De Paula.

[11] On December 21, 2018, the Mariners traded Gamel and Noah Zavolas to the Milwaukee Brewers for Domingo Santana.

[15] On February 11, 2021, Gamel signed a minor league contract with the Cleveland Indians organization that included an invitation to Spring Training.

On February 22, 2023, Gamel signed a minor league contract with the Tampa Bay Rays organization.

On August 14, the Padres selected Gamel's contract, adding him to the major league roster.

On June 25, the Mets selected Gamel's contract, adding him to their active roster to replace Starling Marte after he was placed on the injured list.

[34] On September 17, the Astros placed Gamel on the 10-day IL with a fractured left fibula sustained after running into the outfield wall to make a catch in Anaheim.