The Anglo-Saxon tower of St Bene't's, built sometime between 1000–1050AD, is the oldest standing building in Cambridgeshire.

[5] In this pub, Francis Crick interrupted lunchtime patrons on 28 February 1953 to announce that he and James Watson had discovered the structure of DNA.

The main site of Corpus Christi College is located on the south side of the street.

[8] On the corner of the College with Trumpington Street is the Corpus Clock, installed in 2008.

While at Cambridge University, Clive James and Germaine Greer lived at Friar House,[9] an early-17th-century Grade II listed building with a timber frame and pargeting at the corner of Bene't Street and Free School Lane.