Bicine is an organic compound used as a buffering agent.

It is one of Good's buffers and has a pKa of 8.35 at 20 °C.

[1] It is prepared by the reaction of glycine with ethylene oxide, followed by hydrolysis of the resultant lactone.

[2] Bicine is a contaminant in amine systems used for gas sweetening.

It is formed by amine degradation in the presence of O2, SO2, H2S or Thiosulfate.