Many Good's buffers became and remain crucial tools in modern biological laboratories.
Good sought to identify buffering compounds which met several criteria likely to be of value in biological research.
Piperazine-containing buffers (PIPES, HEPES, POPSO and EPPS) can form radicals and should be avoided in studies of redox processes in biochemistry.
[6] In general, Norman Good and his co-workers attracted attention of the scientific community to the possibility and benefits of using zwitterionic buffers in biological research.
Since then, other zwitterionic compounds, including AMPSO, CABS, CHES, CAPS and CAPSO, were investigated for use in a biological context.