Bone remodeling

Recent research has identified a specialised subset of blood vessels, termed Type R endothelial cells, in the bone microenvironment.

[1] These blood vessels play a crucial role in adult bone remodelling by mediating interactions between bone-resorbing osteoclasts and bone-forming osteoblasts.

Type R blood vessels are characterised by their association with post-arterial capillaries and exhibit unique remodelling properties crucial for bone homeostasis.

[2] These processes also control the reshaping or replacement of bone following injuries like fractures but also micro-damage, which occurs during normal activity.

[6] Bone metabolism relies on complex signaling pathways and control mechanisms to achieve proper rates of growth and differentiation.