Transforming growth factor beta family proteins bind to these receptors.
[1] There are four bone morphogenetic protein receptors:[2] Both type 1 and 2 bone morphogenetic protein receptors have a single transmembrane segment.
[3] Type 1 contains a glycine-serine-rich domain to be phosphorylated by type 2 kinase domain, initiating the signaling transduction pathway of the SMAD signaling cascade.
[3] The wrist epitope motif on BMP-2 has a high-affinity binding site for BMPR-IA.
The knuckle epitope motif on BMP-2 has a low-affinity binding site for BMPR-II.