Bonne Femme Creek is a stream in Howard and Randolph counties in the U.S. state of Missouri.
[2] The stream headwaters arise in Randolph County approximately two miles west of Higbee just southwest of the intersection of routes B and H[3] at 39°18′11″N 92°32′35″W / 39.30306°N 92.54306°W / 39.30306; -92.54306[1] at an elevation of about 850 feet.
It flows to the southeast passing under U.S. Route 40 and on to its confluence with the Missouri approximately two miles east of Booneville.
[1] Bonne Femme Creek is a French name signifying "good woman".
[5] The English and French names for the stream probably are accurate preservations of the Omaha language word for "good woman", i.e. the wife of their Indian religious leader.