Brohm played college football for Louisville and was selected by the Green Bay Packers in the second round of the 2008 NFL draft.

He also played in the NFL for the Buffalo Bills and the CFL's Hamilton Tiger-Cats and Winnipeg Blue Bombers, as well as the Las Vegas Locomotives of the United Football League While passing for 10,579 yards and 119 touchdowns during his prep career, Brohm led the Trinity Shamrocks to the 4-A state title in 2001, 2002,[2] and 2003.

[3] He was the MVP of all three title games, the most exciting of which was a 59–56 victory over Louisville Male High School and 2002 Mr. Football Michael Bush.

[6] Brohm was named one of the top five quarterbacks in America by Rivals.com and was selected to participate in the 2004 U.S. Army All-American Bowl game in San Antonio, Texas.

[8] Brohm announced his decision to attend the University of Louisville on January 20, 2004, picking the hometown Cardinals over scholarship offers from Notre Dame, Tennessee and Alabama, among others.

[9][10][11] Brohm enrolled at Louisville in the fall of 2004 and immediately began competing for the starting quarterback spot with Stefan LeFors.

In 2005, Brohm passed for 2,883 yards and 19 touchdowns before sustaining a season-ending knee injury in a game against Syracuse on November 25.

He was forced to miss Louisville's last regular season game (a December 2 matchup against (Connecticut) and was still in rehabilitation when the Cardinals lost to Virginia Tech in the 2006 Gator Bowl.

"[17] In the 2007 Orange Bowl, Brohm earned MVP honors by leading Louisville to its first-ever BCS victory, 24–13 over Wake Forest.

[24] However, Brohm eventually decided to return for his senior season for another shot at helping the Louisville Cardinals to a BCS National Championship.

In the 2nd quarter of the same game, Brohm threw an 8-yard pass to wide receiver Terrell Owens, giving the wideout his 1,000th career reception.

[citation needed] Brohm signed with the Las Vegas Locomotives of the United Football League on August 29, 2011.

Continuing with a busy 2012 off-season, Brohm was invited to attend the New Orleans Saints rookie mini-camp on a tryout basis.

He saw action beginning in the Week 3 game against the Sacramento Mountain Lions after an injury to Clement; his first play was an 80-yard touchdown pass.

Brohm was among the 78 players from both the Locomotives and Omaha Nighthawks who filed a class-action lawsuit against UFL majority owner Bill Hambrecht for unpaid salary after the 2012 season was cut short.

[41] For the 2020 season opener against Iowa, Brohm took over as acting head coach and play-caller after Jeff tested positive for COVID-19, a game that Purdue won 24–20.