Brookland-Cayce High School is a public high school located in Cayce, South Carolina, United States.

It is part of Lexington County School District 2.

Named for the cities of Brookland (now West Columbia) and Cayce which it originally served, the school now serves parts of West Columbia, Cayce, South Congaree, Pine Ridge, and Gaston.

It is a part of the Lexington County School District Two.

[citation needed] It was founded in order to serve the communities across the Congaree River from Columbia.