The C. R. Joy House, also known as The Grande Anne Bed & Breakfast, was a historic building located in Keokuk, Iowa, United States.

[2] The house was significant as one of the largest and most ornate residences in Keokuk, and its association with the Knoxville, Tennessee architectural firm of George Franklin Barber & Company, which designed it.

[3] Clyde Royal Joy, who had this Queen Anne style house built in 1897, was a local businessman that served as the national director of the YMCA.

[3] The first floor exterior was faced with a light buff sandstone laid in rock-faced broken ashlar with cut stone trim.

The asymmetrical wrap-around porch featured a turret at its north end and a pediment over its entry from the front walk.