The Hugh W. and Sarah Sample House is a historic building located in Keokuk, Iowa, United States.

Hugh Sample became the mayor of Keokuk in 1858 and had the house built the following year.

[3] It follows an irregular plan and features tall narrow windows capped with elaborated crowns, a low pitch gabled roof, and wide bracketed eaves.

At one time the house had an ornate cupola.

The rooms on the interior have 12-foot (3.7 m) ceilings[3] The house was listed on the National Register of Historic Places in 1995.