The E. H. Harrison House is a historic building located in Keokuk, Iowa, United States.

The Federal style is found in the building's large windows, the elliptical doorway arch, the bowed two story front bay, and the brickwork.

Its interior features a unique open, two-story, self-supporting staircase that is said to be one of seven in existence in the United States.

[3] The man who had the house built was Enos H. Harrison, who was a successful businessman originally from Elizabeth, New Jersey.

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