The parish church is the former St. Peter's; St. Francis de Sales was subsequently demolished.

The area of present-day Keokuk was within the Half-Breed Tract, land set aside by the United States Senate on January 18, 1825, for settlement of mixed-race descendants of the Sac and Fox tribes.

Over the years, some of the women had married French trappers who worked the area, and their descendants were excluded from communal lands because their fathers lacked tribal status.

Mixed-race families could live in the Half-Breed Tract but could not sell individual allotments until Congress changed the law in 1837.

Charles Felix Van Quickenborne, SJ the Vicar General of Upper Louisiana, which included the Half-Breed Tract.

Samuel Charles Mazzuchelli, OP from St. Paul's Church in Burlington added Keokuk to his missionary area.

John George Alleman started visiting Keokuk regularly from St. Joseph's in Fort Madison; however, he was unable to raise enough money to build a church.

A future historian of Keokuk, Virginia Wilcox Ivins, remembered seeing the "elegant" priest hammering on the church roof on a hot July day when she was twelve years old.

By now there were quite a few German Catholics in Keokuk, who had immigrated after the 1848 Revolutions, and they wanted a priest who spoke their language.

St. Francis de Sales Church was begun in 1870 to serve the neighborhoods on the east side of town.

In 1886 Franciscan Sisters from Peoria, Illinois opened St. Joseph Hospital next to St. Mary's Church.

The chapel used the angel statues that flanked the high altar at St. Mary's, the pews from St. Francis de Sales, as well as other elements from the three churches.

The Church of All Saints is an outstanding example late Gothic Revival style in the state of Iowa.

The exterior is composed of local clay brick, and magnesium limestone for the coping on the pilasters, window sills and buttresses.

The church's art glass windows were created in Munich, Germany and installed by the A. Misch Company of Chicago in 1884 at a cost of $3,300.

It features quatrefoil, Latin cross and yin-yang-shaped lights that are set within rosette forms.

In the apse on the opposite side of the church is a carved white marble altar.

The former altar frontal bears an image of the Lamb and the scroll with seven seals from the Book of Revelation.

They withdrew from teaching when Father DeCailly wanted to start a high school for girls, and the Notre Dame Sisters felt it would infringe on the Visitation Academy.

The Notre Dame Sisters came back to Keokuk and staffed the parochial school at St. Mary's Church.

Because of low enrollment and financial concerns, Cardinal Stritch consolidated with Holy Trinity High School in Fort Madison in 2006.

[6] St. Vincent's Elementary School, which includes preschool through fifth grade, moved into the former Cardinal Stritch building.