The John N. and Mary L. (Rankin) Irwin House is a historic building located in Keokuk, Iowa, United States.

[2] The house was originally built by James F. Daugherty who bought the property from Judge Charles Mason in 1856.

Irwin bought the house and raised his family here with his wife Mary after his time in Idaho.

A ballroom was located at the top of the house, but on warm summer evenings the parties were moved to the backyard, which was all brick at the time.

The house is located at the crest of a bluff that overlooks the Mississippi River and Lock and Dam No.