83112380ENSG00000153113ENSMUSG00000021585P20810P51125NM_001042445NM_001042446NM_001190442NM_001284212NM_001284213NM_001750NM_173060NM_173061NM_173062NM_173063NM_001330626NM_001330627NM_001330628NM_001330629NM_001330630NM_001330631NM_001330632NM_001330633NM_001330634NM_001375317NM_001301160NM_001301181NM_009817NP_001035910NP_001035911NP_001177371NP_001271141NP_001271142NP_001317555NP_001317556NP_001317557NP_001317558NP_001317559NP_001317560NP_001317561NP_001317562NP_001317563NP_001741NP_775083NP_001362246NP_001288089NP_001288110NP_033947Calpastatin is a protein that in humans is encoded by the CAST gene.

[5][6][7][8] The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor.

[citation needed] The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation.

Several alternatively spliced transcript variants of this gene have been described, but the full-length natures of only some have been determined.

This article on a gene on human chromosome 5 is a stub.