Valencene synthase (EC 4.2.3.73) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (valencene-forming).
[1] It is a terpene cyclase enzyme responsible for the biosynthesis of valencene, a sesquiterpene, using farnesyl pyrophosphate as its substrate.
The first such enzyme was isolated using orange cDNA.
[2] This enzyme catalyses the following chemical reaction The recombinant enzyme from Vitis vinifera forms (+)-valencene and (-)-7-epi-α-selinene.