The river, formed by the confluence of the Castlefern, Craigdarroch and Dalquhat, flows for 11.5 miles (18.5 km) southeast to the Cluden.

[1] The Castlefairn is joined by the Craigdarroch and then by the Dalwhat, both from its left, just below the village of Moniaive in the parish of Glencairn.

Cluden Water flows east and southeast to join the River Nith just north of Dumfries.

[3] The river once defined part of the boundary between Dumfriesshire to the east and Kirkcudbrightshire to the west.

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