Cairo Road is the main thoroughfare of Lusaka, Zambia and the principal business, retail and service centre of the city.

Cairo Road is 1.8 km long, running north–south between the Great East Road junction (also known as the "Kabwe Roundabout") and the Independence Avenue junction (also known as the "Kafue Roundabout"), and is a wide dual carriageway with an avenue of trees down the centre.

This has been partially alleviated by the expansion of Lumumba Road to the west as a by-pass, taking much through traffic.

All Heavy Goods vehicles are required to use Lumumba Road (not allowed on Cairo Road) when travelling from the southern side of the CBD to the northern side of the CBD and vice versa.

This is primarily due to the lack of any major ring roads and the growth of Lusaka's population.