Canajoharie (/ˌkænədʒəˈhɛəri/), also known as the "Upper Castle", was the name of one of two major towns of the Mohawk nation in 1738.

The community stretched for a mile and a half along the southern bank of the Mohawk River, from a village known as Dekanohage westward to what is now Fort Plain, New York.

It contains the Indian Castle Church, built in 1769 for the Mohawk by Sir William Johnson, the British Superintendent of Indian Affairs, on land donated by his consort Molly Brant and her brother Joseph Brant, both leaders among the Mohawk.

For a time the town was the home of the notable Mohawk leaders Hendrick Theyanoguin (1692–1755) and the Brants.

[1] It refers to swirling actions of water in a large circular pothole in the Canajoharie Creek near where it empties into the Mohawk River.