Cayman Islands competed at the 2016 Summer Olympics in Rio de Janeiro, Brazil, from 5 to 21 August 2016.

[2] Among the sports represented by the athletes, Cayman Islands marked its Olympic return in sailing after a sixteen-year absence.

The Caymanian team featured swimming siblings Geoffrey and Lara Butler, Laser Radial sailor Florence Allan, track sprinter Kemar Hyman, and hurdler Ronald Forbes, who joined Kareem Streete-Thompson as the only athletes to compete in three editions of the Games.

[2] The most experienced member of the team, Forbes was chosen by the committee to lead the delegation for the second time as Cayman Islands' flag bearer in the opening ceremony.

M = Medal race; EL = Eliminated – did not advance into the medal race Cayman Islands received a Universality invitation from FINA to send two swimmers (one male and one female) to the Olympics.