It was opened on July 1, 1967, and was named in honour of the 100th anniversary of Canada.

Under the new network, the hospital was officially known as Rouge Valley Centenary.

On December 1, 2016, the Rouge Valley Health System dissolved as the campuses of The Scarborough Hospital (General and Birchmount) and Rouge Valley Centenary merged to form a new administration, tentatively as the Scarborough and Rouge Hospital,[1] and later the Scarborough Health Network in 2018.

[2] The Ajax and Pickering campus joined Lakeridge Health.

As of 2019, the Scarborough Health Network plans to reduce the number of hospital sites from three to two by 2031.