The hospital provides comprehensive pediatric specialties and subspecialties to infants, children, teens, and young adults aged 0–21[4][5][6] throughout the Bronx and New York state.

[8] The Children's Hospital at Montefiore is one of the largest providers of pediatric health services in New York state.

The hospital is attached to Montefiore Medical Center and is affiliated with the Ronald McDonald House of New York.

In the late 1990s Montefiore Medical Center began raising money for the construction of a separate freestanding children's hospital for its pediatric population.

Some units include: As of 2021 Children's Hospital at Montefiore has placed nationally in 5 ranked pediatric specialties on U.S. News & World Report.