In 1883, the Long Island Rail Road opened its Atlantic Branch to Brooklyn, making Jamaica a suburb of New York City.

At that time the founders applied to state officials for a certificate of incorporation, which was granted on February 20, 1892.

[6] Jamaica Hospital's first permanent location opened on June 18, 1898, near the Union Hall Street station on the east side of New York Avenue (Guy Brewer Blvd), a short distance north of South Street.

The new Jamaica Hospital building on Van Wyck Boulevard was completed on August 24, 1924, where the first patient was admitted.

The following day the building was dedicated and Jamaica Hospital formally opened.