Chlorobis(cyclooctene)rhodium dimer is an organorhodium compound with the formula Rh2Cl2(C8H14)4, where C8H14 is cis-cyclooctene.

Sometimes abbreviated Rh2Cl2(coe)4, it is a red-brown, air-sensitive solid that is a precursor to many other organorhodium compounds and catalysts.

The complex is prepared by treating an alcohol solution of hydrated rhodium trichloride with cyclooctene at room temperature.

C-H activation is often catalyzed by chlorobis(cyclooctene)rhodium dimer as demonstrated in the synthesis of a strained bicyclic enamine.

[2] The synthesis of a mescaline analogue involves enantioselective annulation of an aryl imine via a C-H activation.