A chromophobe is a histological structure that does not stain readily, and thus appears relatively pale under the microscope.

Amphophils are epithelial cells found in the anterior and intermediate lobes of the pituitary.

Together, these epithelial cells are responsible for producing the hormones of the anterior pituitary and releasing them into the bloodstream.

Melanotrophs (also, Melanotropes) are another type of chromophobe which secrete melanocyte-stimulating hormone (MSH).

[1] Chromophobe renal cancer is part of a rare, genetic disorder known as Birt–Hogg–Dubé syndrome.