City Creek is a 7.5-mile (12.1 km) tributary of the Santa Ana River in western San Bernardino County in the U.S. state of California.

Its watershed drains about 19.6 square miles (51 km2) on the southwest slopes of the San Bernardino Mountains.

The East Fork begins in a fan-shaped group of gulches south of Heaps Peak and Mount Sorenson, at about 6,000 feet (1,800 m).

From there it runs south-southwest in a canyon past Fredalba, receiving Schenk Creek from the left near the mouth.

It joins the Santa Ana River to the southeast of San Bernardino International Airport.