Moore died after a leisure trip to England, on his way home as a first class passenger on the RMS Titanic when it sank in the North Atlantic.

[3] Soon after his education, Moore explored and developed properties in West Virginia for coal mining, oil, and timber, partnering with Stephen Benton Elkins and Henry Gassaway Davis.

Moore raised cattle and horses on farmland he owned in Montgomery County, Maryland, and had some real estate investments near Leesburg, Virginia.

Moore bought 50 pairs (100) of the dogs and booked first class travel back to the U.S. for himself and his English manservant, Charles Henry Harrington.

[7][10] According to survivor accounts, on the night of the ship's iceberg collision and sinking, Moore was playing cards in the smoking room with his dining companions and fellow Americans, Major Archibald Butt, Harry Elkins Widener, and William Carter (husband of Lucile).

[1][11] Among the stories Moore told that evening was how he had helped a newspaper reporter interview Anse Hatfield, the patriarch on one side of the infamous Hatfield–McCoy feud.

The couple had four more children, the first of whom died young:[1][17] Moore asked architects Jules Henri de Sibour and Bruce Price in 1906 to design a mansion for his family on land his wife had bought in 1901.