The Clarksville Metropolitan Statistical Area is defined by the United States Census Bureau as an area consisting of four counties – two (Montgomery and Stewart) in Tennessee and two (Christian and Trigg) in Kentucky – anchored by the city of Clarksville, Tennessee.

[2] As of 2020, the Clarksville Metropolitan Statistical Area was the 159th largest MSA in the United States.

[3] In 2003, Hopkinsville was removed from the official name as it was no longer considered a principal city.

[4] That year, Stewart and Trigg counties were also added to the MSA.

As of the census[5] of 2000, there were 232,000 people, 83,332 households, and 61,719 families residing within the MSA.