A clear cell's plasma membrane is highly folded, more so on the apical and lateral surfaces.
The cytoplasm of clear cells contains large amounts of glycogen and many mitochondria.
The clear appearance is often due to the accumulation of substances like glycogen, lipids, or mucin within the cells.
This can be a sign of high metabolic activity, which is common in cancer cells as they rapidly grow and divide.
Some of these malignant clear cell tumors are listed below.