Cobbs Creek rises in a pond about 0.5 miles southeast of Leasburg, North Carolina and then flows north and northeast to join Hyco Creek about 3 miles southeast of Semora, North Carolina.

Cobbs Creek drains 11.76 square miles (30.5 km2) of area, receives about 46.2 in/year of precipitation, has a wetness index of 406.62, and is about 70% forested.

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