[2] Species that are treated in the veterinary clinic, including dogs, cats, horses and ferrets, present human-relevant cancers.
[1] One in four dogs older than 2 dies of cancer, a rate that has increased, which may in part be explained by reductions in other causes of death.
Tumor initiation and progression are influenced by age, nutrition, sex, reproduction and environmental exposure.
Canine models support the study of metastasis, disease recurrence and resistance patterns, with relevance to human cancers.
On July 3, 2019 FDA approved selinexor (Xpovio) for multiple myeloma patients who have failed five or more therapies.
If one copy is dysfunctional humans experience Li-Fraumeni syndrome, accompanied by cancer.
One experiment involves lipid spheres loaded with proteins, including a synthetic form of elephant p53.
Naked mole rats experience low cancer rates even though they are smaller than humans.