Cross Run is a tributary of Catawissa Creek in Luzerne County, Pennsylvania, in the United States.

It is approximately 1.1 miles (1.8 km) long and flows through Hazle Township.

Cross Run and its unnamed tributary are considered by the Pennsylvania Department of Environmental Protection to be impaired for part of their lengths.

Cross Run begins immediately east of Pismire Ridge in Hazle Township.

At the southeastern corner of this reservoir, it flows south-southwest for several hundred feet before receiving an unnamed tributary and turning west.

[1] A total of 0.22 miles (0.35 km) of Cross Run is considered by the Pennsylvania Department of Environmental Protection to be impaired for aquatic life by abandoned mine drainage and metals.

[4] Cross Run is in the United States Geological Survey quadrangle of Conyngham.

[7] Cross Run was listed in the Geographic Names Information System on January 1, 1990.