Spies Run is a tributary of Catawissa Creek in Schuylkill County, Pennsylvania, in the United States.

The stream then receives an unnamed tributary and turns north-northwest, entering a much broader valley.

[2] Spies Run is described as a "clean stream" in the January 2013 Progress Report for the Eastern Pennsylvania Coalition for Abandoned Mine Reclamation.

However, laboratory analysis of water samples for the stream determined that its pH was significantly closer to neutral.

[3] A spoon-like geographical feature a mile from Buck Mountain is present at the headwaters of the stream.