The women's time trial class C4-5 track cycling event at the 2020 Summer Paralympics took place on 27 August 2021 at the Izu Velodrome, Japan.

This combined class of (C4-5) under classification C is for cyclists who have impairments that affect their legs, arms, and/or trunk but are still capable to use a standard bicycle.

11 cyclists from 10 nations competed in this event.

[1] The competition immediately begins with the finals, where the 11 cyclists will individually in their own heat, compete by doing a time trial basis where the fastest cyclist will win gold, the 2nd fastest a silver, and the 3rd fastest a bronze.

Cyclists may have a different official time than their real-time due to this event being a combined class event (C1-3), and some cyclists in their own class may have a disadvantage over other classes (for example due to speed), thus athlete factor was used where those in C4 HAS 98.91 and C5 100.00.