It was the final theatrical production in which Mel Blanc provided the voices of the various Looney Tunes characters before his death in July 1989.

Unlike previous compilation films, Quackbusters uses pre-existing music from older Looney Tunes shorts composed by Carl Stalling, Milt Franklyn and William Lava for both the new animation and classic footage.

Most of the films included in the compilation have a comedy horror theme, with stories involving spirit possession, exorcism, Transylvanian vampires, magic words, and Yetis.

The money is locked in a safe, under the provision that it will be used to provide a beneficial public service and Daffy follow Cubish's creed to display honesty in business affairs.

When the city is swept with reports of a tiny elephant, Daffy, presuming this to be mere hysteria, hopes to profit by soothing the public with his "expert" testimony.

However, no sooner does he announce to the audience that there is no such thing as a tiny elephant when it turns up on Daffy's television interview, rendering him a public laughing stock.

In the epilogue, Bugs enjoys his vacation in Palm Springs and reads about Daffy's downfall, while Porky and Sylvester are stranded in the Superstition Mountains.

The film was released on VHS on July 19, 1989 (just nine days after Mel Blanc's death), and later on DVD in the United States on August 4, 2009, by Warner Home Video.