[6] After graduating from Indio High School in 1978,[1] she attended the University of California, Los Angeles where she majored in kinesiology.
Her voice roles include the title character from the first CGI film Jimmy Neutron: Boy Genius and its CGI TV series The Adventures of Jimmy Neutron, Boy Genius, Wednesday in Hanna-Barbera's The Addams Family, Tinker Bell on Fox's Peter Pan & the Pirates, Nergal Jr. in The Grim Adventures of Billy & Mandy, Jay Jay, Herky, Savannah, and Revvin' Evan from Jay Jay the Jet Plane (Following the death of Mary Kay Bergman), Tad on various LeapFrog animated videos and DVD's from 2003 to 2004, Coco Bandicoot in the Crash Bandicoot series, Draculaura in Monster High, and Maureen Murphy in F is for Family.
In English language dubs of anime series, she provided the voice of Ryo-Ohki in Tenchi Muyo.
In addition, Derryberry has also provided voice-over for Ice Age: The Meltdown, as the voice of Wednesday Addams in the 1990s animated version of The Addams Family, Weenie and Catrina on Oswald, Taz's little brother Jake on Taz-Mania, Coco Bandicoot in the Crash Bandicoot video game series, and Clay in some Playhouse Disney segments.
She has also done voice work for comedic English language adaptations of anime titles such as Zatch Bell!