Decamethonium (Syncurine) is a depolarizing muscle relaxant or neuromuscular blocking agent,[1] and is used in anesthesia to induce paralysis.

In the process of binding, decamethonium activates (depolarizes) the motor endplate - but since the decamethonium itself is not degraded, the membrane remains depolarized and unresponsive to normal acetylcholine release.

Decamethonium does not produce unconsciousness or anesthesia, and its effects may cause considerable psychological distress while simultaneously making it impossible for a patient to communicate.

For these reasons, administration of the drug to a conscious patient is strongly advised against, except in necessary emergency situations.

[citation needed] This drug article relating to the musculoskeletal system is a stub.