As Deer Creek flows south through the Mississippi Delta, it passes through the following counties: Bolivar, Washington, Sharkey, Issaquena, and Warren; and through the following communities: Metcalfe, Stoneville, Leland, Burdett, Arcola, Hollandale, Panther Burn, Nitta Yuma, Anguilla, Rolling Fork, Cary, Onward, and Valley Park.

Prior to the Civil War the stream was navigable and accessible to the Mississippi River at Lake Bolivar.

[1] The Deer Creek watershed is connected to the Big Sunflower River via the Rolling Fork Creek, a connection that occurs only at high water stages and can flow either way.

[2] During the Civil War, a battery of field guns was shipped up the stream to be carried to positions on the Mississippi River at "Greenville Bends" to fire on the U.S.

This article related to a river in Mississippi is a stub.