[citation needed] The manga was adapted into a twenty-six episode anime series by TMS Entertainment from 1998–1999, which was released in the US by ADV Films in 2003–2004, and later available through streaming by Midnight Pulp.

Set in Japan after the events of Devilman, the story follows Jun Fudo, a teacher and former athlete who lives alone with her younger brother, Hikaru, while their father is away in the United States.

Confused by her transformation, Lan Asuka, and her father's sudden appearance and experience, things became too complicated for Jun.

Professor Fudo knowledge tells a tale of a strange phenomenon that occurred in shantytowns years ago.

It was known as the "Devil Beast Syndrome" in which causes its human hosts to mutate into demon-like mutants and rape women before eating them with no memories or intelligence of their previous lives and additionally giving them enhanced strength with other abilities.

Professor Fudo does not believe that their "Devil Beast Syndrome" transformation was supernatural, but was actually the next stage of human evolution, calling it "Nature's way of dealing with mankind's overpopulation".

He states that few people were genetically engineered to retain their conscience should the "Devil Beast Syndrome" occur in them, although Jun is one of them.

Once they reach the lowest point of Hell, they realize that the demon king is there frozen in ice, but Satan is nowhere to be found.

The manga ends with Satan telling Akira that true hope lies on the other side of the battle as they are launching their attack.

She has a secret that not even she knows about at first, for within her lie the genes that hold the next step in the evolution of mankind, the same blood as the beast-like superhumans that terrorize the city.

Unlike them, Jun manages to hold a tenuous grip on her humanity and gets recruited by the mysterious Lan Asuka, a member of a secret organization within the government aimed at controlling, if not eliminating, these berserk destroyers of mankind.

The story of the anime differs significantly from the manga, despite having similar beginnings – devils are not mystical beings but the next step of humanity's evolution.

Four bird-like devil beasts commanded by Satoru in the last third of the series with each possessing the ability to control a specific element.

Jun is portrayed as tougher and braver – she stands up for herself and rarely needs others to save her, while in the manga; she is often a damsel in distress.

[citation needed] Cutie Honey vs. Devilman Lady, a crossover manga between Devil Lady and another series of Nagai's, Cutie Honey, was written and illustrated by Nagai and published by Akita Shoten in Champion Red Ichigo from June 5 – October 4, 2013.

[18] On June 12, 2015, the Chinese Ministry of Culture listed Devilman Lady among 38 anime and manga titles banned in China.