It is used in many cosmetics, skin care products, shampoos and conditioners, as well as a wide range of products including bubble baths, baby wipes and household detergents.

Commercial diazolidinyl urea is a mixture of different formaldehyde addition products including polymers.

[2] Diazolidinyl urea is produced by the chemical reaction of allantoin and formaldehyde in the presence of sodium hydroxide solution and heat.

The reaction mixture is then neutralized with hydrochloric acid and evaporated: Diazolidinyl urea was poorly characterized until recently and the single Chemical Abstracts Service structure assigned to it is probably not the major one in the commercial material.

Instead, new data indicate that one of the hydroxymethyl functional groups of the imidazolidine ring is attached to the carbon, rather than on the urea nitrogen atom:[2] Some people have a contact allergy to imidazolidinyl urea causing dermatitis.