[5][6] His father, Oskar, who was Jewish, was born in Ukraine, and worked as a physician after graduating from the Third Medical Institute of Moscow,[7][8] while his mother, an ethnic Russian, was a mathematics professor.

During his first year in the NYIT medical portion of the accelerated program, his mother died of leukemia, and he decided to move back in with his father.

In 2014, he started a residency at Atlantic Health System's Overlook Medical Center's Family Medicine program,[13] which he completed in 2017.

[5] In 2017, a year after he launched his YouTube channel, Varshavski gave a TEDx Talk on "The epidemic of the 'I Know It All' expert" at a TEDxMonteCarlo event.

[20] In March 2020, Varshavski interviewed Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases (NIAID), about the pandemic.

Guests have included Steve-O, KSI,[28] Tony Hale, Dane Cook, Hannah Brown, Marques Brownlee, Steve Madden, Steven He, Barbara Corcoran, Kal Penn, and Brandon Marshall.

[citation needed] In late 2015, Varshavski established a foundation, Limitless Tomorrow, to provide scholarships to students, and he has raised money for it by auctioning experiences with himself through his social media accounts.

[33][34] In 2016, he and Filipino actress and 2015 Miss Universe Pia Wurtzbach met at a charity event in New York and started dating.