Domingos Leite Pereira (Portuguese: [duˈmĩɡuʒ ˈlɐjtɨ pɨˈɾɐjɾɐ]; 19 September 1880[1] – 27 October 1956) was a Portuguese politician of the Portuguese First Republic.

He had degrees in theology and literature of the University of Coimbra.

He helped to improve the relationships between the republic and the Catholic Church during his government.

During his life he served in many political posts: After the 28 May 1926 revolution that installed the Ditadura Nacional (National Dictatorship) that would be followed by António de Oliveira Salazar's fascist Estado Novo (New State) regime, he abandoned his political life.

Until the end of his life in 1956, he served as President of the insurance company Douro.