It is located on the Wellcome Genome Campus in Hinxton near Cambridge, and employs over 600 full-time equivalent (FTE) staff.

[4] Further, the EMBL-EBI hosts training programs that teach scientists the fundamentals of the work with biological data and promote the plethora of bioinformatic tools available for their research, both EMBL-EBI-based and not so.

The highest scoring sequences represent the closest relatives of the query, in terms of functional and evolutionary similarity.

Users may also designate the specific databases to be searched, select scoring matrices to be used and other parameters prior to the tool run.

[9] Clustal Omega algorithm employs two profile Hidden Markov models (HMMs) to derive the final alignment of the sequences.

[10] The main advantage of Clustal Omega over other MSA tools (Muscle, ProbCons) is its efficiency, while maintaining a significant accuracy of the results.

[18] The first release of the database was in 2021; as of 2024[update], AlphaFold DB provides access to over 214 million protein structures.