East Branch Louse Creek is a 2.79 mi (4.49 km) long second-order tributary to Louse Creek in Holt County, Nebraska.

The confluence of this creek with West Branch Louse Creek forms Louse Creek.

East Branch Louse Creek rises on the Steel Creek divide about 4 miles (6.4 km) southwest of Dorsey, Nebraska in Holt County and then flows northwest to join West Branch Louse Creek and forms Louse Creek about 4 miles (6.4 km) west of Dorsey, Nebraska.

[1] East Branch Louse Creek drains 5.56 square miles (14.4 km2) of area, receives about 24.9 in/year (63 cm/year) of precipitation, and is about 0.05% forested.

This article related to a river in Nebraska is a stub.