As of August 2023, her YouTube channel had reached 12 million subscribers and accumulated a total of 1.61 billion video views.

[15] Chamberlain's content included cooking videos, fashion hauls, car vlogs, collaborations with fellow Youtubers, among others.

[16] Chamberlain gained notoriety for her unique editing style, characterized by zooms, adding text to the screen, and pauses.

[2] There, she formed the Sister Squad with fellow teen YouTubers James Charles and comedy duo The Dolan Twins.

Chamberlain's one-on-one onstage interview with Mongeau was the last event before the convention was canceled due to overcrowding and security concerns.

[22] At VidCon 2019, Snapchat announced that Chamberlain would be one of several celebrities from various entertainment platforms to premiere a Creator Show later in the year.

[27] She attended her second Louis Vuitton-sponsored Paris Fashion Week, collaborating with Vogue for a preparation video about the process.

[30] She appeared in a series of videos on the Target YouTube channel, being paired with The Office star Angela Kinsey and Fashion Police host Brad Goreski.

"[33][34] In December 2019, she was featured in a segment broadcast on ABC News Nightline, being interviewed about her career by Olympic figure skater Adam Rippon.

[35] In November 2022, she appeared on Hot Ones with Sean Evans, getting interviewed while eating increasingly spicy (plant-based) chicken wings.

In May, 2018 Dote sent her to Austin, Texas, to the Coachella Valley Music and Arts Festival, and to Fiji with numerous other female YouTubers.

[46] Cosmopolitan featured Chamberlain on the cover of its February 2020 issue, writing the caption below her name, "The most popular girl in the world".

In the interview she revealed details of dealing with body dysmorphia and struggling with eating disorders,[47] and she posted a video about the photo shoot to her YouTube channel, My First American Magazine Cover.

[54] Recorded prior to the COVID-19 pandemic, on April 16 she appeared in an episode of Kevin Hart's YouTube series What The Fit, playing soccer with the LA Galaxy.

She will feature in a web series on Lancome's YouTube channel that will also appear in shorter formats on Instagram and TikTok.

[63] On April 11, 2019, Chamberlain launched the first episode of her podcast, Anything Goes (previously named Stupid Genius), a weekly series in which she attempts to make an ongoing conversation about any particular issue/topic.

The program was produced by Ramble Official in a partnership with Cadence13 and United Talent Agency, until February 2023 when it became a Spotify exclusive.

In 2023, Chamberlain was cast as the voice of a reporter in the animated teen fantasy comedy film Ruby Gillman, Teenage Kraken.

During the interview she spoke with many prominent celebrities, including Jack Harlow whose awkwardly flirtatious interaction went viral online.